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Cannabis - Cannabinoid and Terpenoid Biosynthesis
Project Goals:..............Understanding the regulatory networks that lead to the accumulation of specific combinations of cannabinoids and terpenoids
Since the original structural elucidation of tetrahydrocannabinol (THC) as a psychoactive principle in cannabis in the 1960s, the structures of more than 90 biogenic cannabinoids have been reported, some of which have shown promise in preclinical investigations. A second class of metabolites with high abundance in cannabis are monoterpenes and sesquiterpenes, which impart the distinctive aromas of different strains. We are developing integrative approaches that allow the unequivocal differentiation of cannabis strains. Our biochemical research identifies the properties of genes and enzymes responsible for the formation of specific cannabinoids and terpenoids.
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