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Cannabis - Cannabinoid and Terpenoid Biosynthesis

Project Goals:..............Understanding the regulatory networks that lead to the accumulation of specific combinations of cannabinoids and terpenoids
Funding:
......................Private Donors
Collaborators:
.............Anthony Smith - Evio Labs
....................................Jordan Zager, Paul Mihalyov - Dewey Scientific
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Executive Summary

Since the original structural elucidation of tetrahydrocannabinol (THC) as a psychoactive principle in cannabis in the 1960s, the structures of more than 90 biogenic cannabinoids have been reported, some of which have shown promise in preclinical investigations. A second class of metabolites with high abundance in cannabis are monoterpenes and sesquiterpenes, which impart the distinctive aromas of different strains. We are developing integrative approaches that allow the unequivocal differentiation of cannabis strains. Our biochemical research identifies the properties of genes and enzymes responsible for the formation of specific cannabinoids and terpenoids.

Popular Press Coverage

Forbes.com

National Geographic

Spokesman Review

WSU Insider

Selected Recent Publications

Zager J.J., Lange I., Srividya N., Smith A., Lange B.M. (2019) Gene networks underlying cannabinoid and terpenoid accumulation in cannabis. Plant Physiol. 180, 1877-1897.

Zager J.J., Lange B.M. (2018) Assessing flux distribution associated with metabolic specialization of glandular trichomes. Trends Plant Sci. 23, 638-647.