...
Home....................................... ....

Contact

Research

Teaching

Publications

Staff

Links

Web-based tools
(Lange lab developments)

BioPathAt
Biochemical pathway maps for integrative analysis of post-genomic data sets

MGR
Comprehensive online genomics and metabolism resource for the mint family

Spektraris
Accurate mass - time tag (AMT) and NMR spectral libraries for plant natural products (21,000 records)

Research infrastructure

M.J. Murdock Metabolomics Laboratory
Analytical service center for metabolomics research

 

 

 

The Lange laboratory investigates the biosynthesis of plant natural products (with an emphasis on terpenoids) using functional genomics and systems biology approaches. We are developing mathematical models to quantitatively describe the regulation of metabolic pathways. Our models enable knowledge-based pathway improvements by breeding or metabolic engineering.

We are particularly interested in understanding metabolism in specialized plant cell types, which are responsible for the synthesis of essential oils, oleoresins, and pharmaceutically relevant natural products.

Group Meetings
Friday, March 22, 2019...................................................................................................1:00 to 4:00 PM
Friday, April 8, 2019.......................................................................................................1:00 to 4:00 PM

Lab Seminar
TBD

..

..Last updated:
January 31, 2019

Lange Laboratory News:

2019 (February 28)
An article reporting on our collaborative work (with colleagues at Oregon State University and the National Center for Germplasm Resources) on the genetic and chemical diversity of ancestral mint species is published online in Genetic Resources and Crop Evolution (WebLink to article).

2019 (February 26)
Joel Velasco joins the Lange Laboratory as a graduate student (Molecular Plant Sciences Program). Welcome, Joel!

And . . . , no, he is not wearing a tie at work.

2019 (January 23)
Mark Lange gives an invited lecture at the Annual Conference of the Mint Industry Research Council in San Antonio, TX.

2019 (January 10)
Mark Lange gives an invited lecture at the Annual Meeting of the Oregon Mint Commission in Gleneden Beach, OR.

2019 (January 8)
Our review article on monoterpene functionalization reactions in glandular trichomes is published online in Journal of Experimental Botany (WebLink to article).

2018 (December 8)
Jordan Zager graduates with a degree in Molecular Plant Sciences. Congratulations, Dr. Zager! Jordan is starting up an agricultural biotechnology company, so he looks pretty happy, while Mark's smile looks suspicious. Maybe it's that gown . . .

2018 (December 4)
Mark Lange gives an invited lecture at the Washington Mint Convention in Kennewick, WA.

2018 (October 11)
Our article reporting on oleoresin biosynthesis in loblolly pine resin ducts is published online in Journal of Experimental Botany (WebLink to article). In the published issue of the journal (January 1st, 2019), the paper is featured in an "Insights" article written by Harro Bouwmeester.

2018 (August 30)
Our article reporting on the roles of a particular family of bHLH transcription factors in apical meristem fucnction is published online in Plant Signaling and Behavior (WebLink to article) as cover paper of the journal.

2018 (May 4)
Our article sumarizing the outcomes of a meta-analysis of metabolism in plant glandular trichomes (incorporating genome-scale models for various species) is published online in Trends in Plant Science (WebLink to article).

2018 (April 25)
Jana Richter (third from right) has her last day as a visiting M.Sc. student. She is going back to Germany to finish her thesis. All the best, Jana!

2018 (March 14)
Chanchan Liu (center, with present) has her last day as a visiting Ph.D. student. She is going back to China to finish her dissertation. All the best, Chanchan!

2018 (March 10)
Our paper reporting on the developmental dynamics of essential oil biosynthesis in Japanese catnip (collaboration with Dr. Qianan Wu and colleagues at
Nanjing University of Chinese Medicine) is published online in Phytochemistry (WebLink to article).

2018 (February 23)
Mark Lange gives an invited lecture at the Cornell University in Ithaca, NY.

2018 (February 6)
Our mass spectrometric analyses of novel intermediates of coenzyme M biosynthesis in
Xanthobacter autotrophicus, which are part of collaborative efforts with John Peters' lab at the IBC, are published online in Journal of Biological Chemistry (WebLink to article).

2018 (February 4-9)
Mark Lange serves as Co-Chair for the Gordon Conference on Plant Volatiles in Barga, Italy.

2018 (January 24)
Mark Lange gives an invited lecture at the Annual Conference of the Mint Industry Research Council in New Orleans, LA.

2018 (January 12)
Mark Lange gives an invited lecture at the Oregon Mint Convention in Gleneden Beach, OR.

2017 (December 5)
Mark Lange gives an invited lecture at the Washington Mint Convention in Yakima, WA.

2017 (November 18)
Our review article on plant tissue culture for specialty chemical production is published online as part of the book Biotechnology of Plant Natural Products (WebLink to article). Mark Lange also served as one of the editors for this book.

2017 (November 7)
Fima Inabuy defends her dissertation at 10 AM, in CUB 406. Congratulations, Dr. Inabuy! (Fima is in the center of the first row in the photo below).

2017 (August 24)
Our paper reporting on the bioenergeticts of monoterpene biosynthesis in mint glandular trichomes is published online in Plant Physiology (WebLink to article).

2017 (August 4-9)
Mark Lange assumes the
presidency of the Phytochemical Society of North America at the Annual Conference in Columbia, MO, USA.

(giving out awards - the fun stuff!)

2017 (July 18)
Our paper reporting on the development of Tripterygium adventitious root cultures for the production of pharmaceutically relevant diterpenoids is published online in Plant Physiology (WebLink to article).