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Access to Lange laboratory research papers via Google Scholar.

Chronoligical Listing

Lange B.M. (2020) Flux distribution at the interface of central carbon metabolism and terpenoid volatile formation. In Biology of Plant Volatiles, Eran Pichersky, Natalia Dudareva, Eds., CRC Press, Boca Raton, FL, in press. Link

Srividya N., Lange I., Hartmann M., Li Qunrui, Mirzaei M., Lange B.M. (2020) Biochemical characterization of acyl activating enzymes for side chain moieties of taxol and its analogs. J. Biol. Chem. 289, in press.

Parrish AN, Tuner GW, Lange B.M. (2020) High contribution of canopy to oleoresin accumulation in loblolly pine trees. bioRxiv doi: https://doi.org/10.1101/2020.04.09.034264. Link

Lange B.M., Poirier B.C., Lange I., Schumaker R., Rios-Estepa R. (2020) Organ-specificity of sterol and triterpene accumulation in Arabidopsis thaliana. bioRxiv doi: https://doi.org/10.1101/2020.03.23.004358. Link

Ahkami A.H., Wang W., Wietsma T.W., Winkler T., Lange I., Jansson C., Lange B.M., McDowell N.G. (2019) Metabolic shifts associated with drought-induced senescence in Brachypodium. Plant Sci. 289, 110278.

Samec D., Pierz V., Srividya N., Wuest M., Lange B.M. (2019) Assessing chemical diversity in Psilotum nudum (L.) Beauv., a pantropical whisk fern that has lost many of its fern-like characters. Front. Plant Sci. 10, 868

Zager J.J., Lange I., Srividya N., Smith A., Lange B.M. (2019) Gene networks underlying cannabinoid and terpenoid accumulation in cannabis. Plant Physiol. 180, 1877-1897.

Vining K., Pandelova I., Hummer K., Bassil N., Contreras R., Neill K., Chen H., Parrish A.N., Lange B.M. (2019) Genetic diversity survey of Mentha aquatica L. and Mentha suaveolens Ehrh., mint crop ancestors. Genet. Res. Crop Evol., 66, 825-845. Link

Lange B.M., Srividya N. (2019) Enzymology of monoterpene functionalization in glandular trichomes. J. Exp. Bot., 70, 1095-1108.

Turner G.W., Parrish A.N., Zager J.J., Fischedick J.T., Lange B.M. (2019) Assessment of flux through oleoresin biosynthesis in epithelial cells of loblolly pine resin ducts. J. Exp. Bot. 70, 217-230.

Poirier B.C., Feldman M.J., Lange B.M. (2018) bHLH093/NFL and bHLH061 are required for apical meristem function in Arabidopsis thaliana. Plant Signal. Behav. 13, e1486146.

Zager J.J., Lange B.M. (2018) Assessing flux distribution associated with metabolic specialization of glandular trichomes. Trends Plant Sci. 23, 638-647.

Liu C., Srividya N., Parrish A.N., Yue W., Shan M., Wu Q., Lange B.M. (2018) Morphology of glandular trichomes of Japanese catnip (Schizonepeta tenuifolia Briquet) and developmental dynamics of their secretory activity. Phytochemistry 150, 23-30.

Partovi S.E., Mus F., Gutknecht A.E., Martinez H.A., Tripet B.P., Lange B.M., DuBois J.L., Peters J.W. (2018) Coenzyme M biosynthesis in bacteria involves phosphate elimination by a functionally distinct member of the aspartase/fumarase superfamily. J. Biol. Chem. 293, 5236-5246.

Lange B.M. (2018) Commercial-Scale Tissue Culture for the Production of Plant Natural Products: Successes, Failures and Outlook. In Biotechnology of Natural Products, W. Schwab, B.M. Lange, M. Wuest, Eds., Nature Springer, pp. 189-218. Link

Johnson S.R., Lange I., Srividya N., Lange B.M. (2017) Bioenergetics of monoterpenoid essential oil biosynthesis in non-photosynthetic glandular trichomes. Plant Physiol. 175, 681-695.

Inabuy F., Fischedick J.T., Lange I., Hartmann M., Srividya N., Parrish A.N., Xu M., Peters R.J., Lange B.M. (2017) Biosynthesis of diterpenoids in Tripterygium adventitious root cultures. Plant Physiol. 175, 92-103.

Vincelli P., Jackson-Smith D., Holsapple M., Grusak M.A., Harsh M., Klein T., Lambert J., Lange B.M., Lodge D.M., McCluskey J., Murphy A., Neuhouser M.L., Pray C., Weller S. (2017) National Academies report has broad support. Nature Biotechnol. 3, 304-306.

Lange B.M., Fischedick J.T., Lange M.F., Srividya N., Šamec D., Poirier B.C. (2017) Integrative approaches for the identification and localization of specialized metabolites in Tripterygium roots. Plant Physiol. 173, 456-469.

Vining K.J., Johnson S.R., Ahkami A., Lange I., Parrish A.N., Trapp S.C., Croteau R.B., Straub S.C., Pandelova I., Lange B.M. (2017) Draft genome sequence of Mentha longifolia and development of resources for mint cultivar improvement. Mol. Plant 10, 323-339.

Srividya N., Lange I., Lange B.M. (2016) Generation and functional evaluation of designer monoterpene synthases. Methods Enzymol. 576, 147-165. Link

Lange, B.M. (2016) Online resources for gene discovery and biochemical research with aromatic and medicinal plants. Phytochem. Rev. 15, 489-510. Link

Lange I., Poirier B.C., Herron B.K., Lange B.M. (2015) Comprehensive assessment of transcriptional regulation facilitates metabolic engineering of isoprenoid accumulation in Arabidopsis. Plant Physiol. 169, 1595-1606.

Turner G.W., Lange B.M. (2015) Ultrastructure of grapefruit secretory cavities and immunocytochemical localization of (+)-limonene synthase. Int. J. Plant Sci., 176, 643-661. Link

Feldman M.J., Poirier B.C., Lange B.M. (2015) Misexpression of the Niemann-Pick disease type C1 (NPC1)-like protein in Arabidopsis causes sphingolipid accumulation and reproductive defects. Planta 242, 921-933.

Lange B.M. (2015) The evolution of plant secretory structures and emergence of terpenoid chemical diversity. Annu. Rev. Plant Biol. 66, 139-159.

Lange B.M. (2015) Biosynthesis and biotechnology of p-menthane monoterpenes, including menthol, carvone and limonene. Adv. Biochem. Eng. Biotechnol. 148, 319-353.

Fischedick J.T., Johnson S.R., Ketchum R.E.B., Croteau R.B., Lange B.M. (2015) NMR spectral search module for Spektraris, an online resource for plant natural product identification – taxane diterpenoids from Taxus x media cell suspension cultures as a case study. Phytochemistry 113, 87-95.

Srividya N., Davis E.M., Croteau R.B., Lange B.M. (2015) Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase. Proc. Natl. Acad. Sci. USA 112, 3332-3337.

Kim T., Dreher K., Nilo-Poyanco R., Lee I., Fiehn O., Lange B.M., Nikolau B.J., Sumner L., Welti R., Wurtele E.S., Rhee S.Y. (2015) Patterns of metabolite changes identified from large-scale gene perturbations in Arabidopsis using a genome-scale metabolic network. Plant Physiol. 167, 1685-1698.

Johnson S.R., Lange B.M. (2015) Open-access metabolomics databases for natural product research: present capabilities and future potential. Frontiers Bioeng. Biotechnol. 3, 22.

Ahkami A., Johnson S.R., Srividya N., Lange B.M. (2015) Multiple levels of regulation determine monoterpenoid essential oil compositional variation in the mint family. Mol. Plant 8, 188-191.

Voo S.S., Lange B.M. (2014) Sample preparation for single cell transcriptomics - essential oil glands in Citrus fruit peel as an example. Methods Mol. Biol. 1153, 203-212.

Srividya N., Heidorn D.B., Lange B.M. (2014) Rapid purification of gram quantities of ß-sitosterol from a commercial phytosterol mixture. BMC Res. Notes 7, 182.

Lange B.M., Rios-Estepa R. (2014) Kinetic modeling of plant metabolism and its predictive power – peppermint essential oil biosynthesis as an example. Methods Mol. Biol. 1083, 287-311.

Lange B.M. (2013) Linking metabolomics with quality traits in crop plants. Hot Topics in Metabolomics: Food and Nutrition, Future-Science Ltd., London, UK, pp 66-74. Link

Lange B.M., Lange I., Turner G.W., Herron B.K. (2013) Utility of aromatic plants for the biotechnological production of sustainable chemical and pharmaceutical feedstocks. Med. Aromat. Plants 2, 5. Link

May B., Lange B.M., Wüst M. (2013) Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. Phytochemistry 95, 135-144.

Cuthbertson D.J., Johnson S.R., Piljac-Zegarac J., Kappel J., Schäfer S., Wüst, M., Ketchum R., Croteau R.B., Marques J.V., Davin L.B., Lewis N.G., Rolf M., Kutchan T.M., Seojarto D.D., Lange B.M. (2013) Accurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plants. Phytochemistry 91, 187-197.

Lange B.M., Ahkami A. (2013) Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes - current status and future opportunities. Plant Biotechnol. J. 11, 169-196.

Voo S.S., Grimes H.D., Lange B.M. (2013) Cell type-specific transcriptome analysis provides insights into the functional roles of soybean leaf paraveinal mesophyll. Plant Mol. Biol. Rep. 31, 210-221. Link

Lange B.M., Turner G.W. (2013) Terpenoid biosynthesis in secretory glandular trichomes - current status and future opportunities. Plant Biotechnol. J. 11, 2-22.

Cuthbertson D.J., Andrews P., Reganold J., Davies N., Lange B.M. (2012) Utility of metabolomics toward assessing the metabolic basis of quality traits in apples fruit with an emphasis on antioxidants. J. Agric. Food Chem. 60, 8552-8560.

Cuthbertson D., Piljac-Zegarac J., Lange B.M. (2012) Validation of a microscale extraction and high throughput analysis method for huperzine A in Huperzia . Biomed. Chromatogr. 26, 1191-1195.

Voo S.S., Grimes H.D., Lange B.M. (2012) Assessing the biosynthetic capabilities of secretory glands in Citrus peel. Plant Physiol. 159, 81-94.

Turner G.W., Cuthbertson D.J., Voo S.S., Settles M.L., Grimes H.D., Lange B.M. (2012) Experimental sink removal induces stress responses, including shifts in amino acid and phenylpropanoid metabolism, in soybean leaves. Planta 235, 939-954.

Quanbeck, S.M., Brachova L., Campbell A.A., Guan X., Perera A., He, K., Rhee S., Bais P., Dickerson J.A., Dixon P., Wohlgemuth G., Fiehn O., Barkan L., Lange I., Lange B.M. , Lee I., Cortes D., Salazar C., Shuman J., Shulaev V., Huhman D.V., Sumner L.W., Roth M.R., Welti R., Ilarslan H., Wurtele, E.S., Nikolau B.J. (2012) Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of “unknown function”. Frontiers Plant Sci. 3, Article 15. Link

Lange B.M., Mahmoud S.S., Wildung M.R., Turner G.W., Davis E.M., Lange I., Baker R.C., Boydston R.A., Croteau R.B. (2011) Improving peppermint essential oil yield and composition by metabolic engineering. Proc. Natl. Acad. Sci. USA 108, 16944-16949.

Turner G.W., Grimes H.D., Lange B.M. (2011) Soybean vegetative lipoxygenases are not vacuolar storage proteins. Funct. Plant Biol. 38, 778-787. Link

Rios-Estepa R., Lange I., Lee J.M., Lange B.M. (2010) Mathematical modeling-guided evaluation of biochemical, developmental, environmental and genotypic determinants of essential oil composition and yield in peppermint leaves. Plant Physiol. 152, 2105-2119 (COVER STORY).

Bais P., Moon S.M., He K., Leitao R., Dreher K., Walk T., Sucaet Y., Barkan L., Wohlgemuth G., Roth M.R., Wurtele E.S., Dixon P., Fiehn O., Lange B.M., Shulaev V., Sumner L.W., Welti R., Nikolau B.J., Rhee S.Y., Dickerson J.A. (2010) PlantMetabolomics.org: A web portal for Plant Metabolomics Experiments. Plant Physiol. 152, 1807-1816.

Ghassemian M., Lutes J., Tepperman J.M., Chang H.S., Lange I., Chen W., Zhu T., Wang X., Lange B.M. (2008) Abscisic acid-induced modulation of redox control pathways in Arabidopsis thaliana. Phytochemistry 69, 2899-2911.

Cruz J.A., Emery C., Wuest M., Kramer D.M., Lange B.M. (2008) Metabolite profiling of Calvin cycle intermediates by HPLC-MS using mixed-mode stationary phases. Plant J. 55, 1047-1060.

Rios-Estepa R., Turner G.W., Lee J.M., Croteau R.B., Lange B.M. (2008) A systems biology approach identifies biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint. Proc. Natl. Acad. Sci. USA 105, 2818-2823.

Fiehn O., Sumner L.W., Rhee S.Y., Ward J., Dickerson J., Lange B.M., Lane G., Roessner U., Last R., Nikolau B. (2007) Minimum reporting standards for plant biology context information in metabolomic studies. Metabolomics 3, 195-201. Link

Rios-Estepa R., Lange B.M. (2007) Experimental and mathematical approaches to modeling plant metabolic networks. Phytochemistry 68, 2351-2374.

Mandaokar M., Thines B., Shin B., Lange B.M., Choi G., Koo Y.J., Yoo Y.J., Choi Y.D., Choi G., Browse J.B. (2006) Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling. Plant J. 46, 984-1008 (COVER STORY).

Ghassemian M., Lutes J., Tepperman J.M., Chang H.S., Zhu T., Wang X., Quail P.H., Lange B.M. (2006) Integrative analysis of transcript and metabolite profiling data sets to evaluate the regulation of biochemical pathways during photomorphogenesis. Arch. Biochem. Biophys.448, 45-59.

Lange B.M. (2006) Integrative analysis of metabolic networks: from peaks to flux models? Curr. Op. Plant Biol. 9, 220-226.

Lange B.M. (2006) Biotechnology of isoprenoid production. In Plant Genetic Engineering Vol. 7: Metabolic Engineering & Molecular Farming, Jaiwal, P.K., ed., Studium Press LLC, Houston , TX , pp 261-277. Link

Lange B.M. (2005) Single-cell genomics. Curr. Op. Plant Biol. 8, 236-241.

Lange B.M., Ghassemian M. (2005) Comprehensive post-genomic data analysis approaches integrating biochemical pathway maps. Phytochemistry 66, 413-451.

Browse J., Lange B.M. (2004) Counting the cost of a cold-blooded life. Proc. Natl. Acad. Sci. USA 101, 14996- 14997.

Jenkins H., Hardy N., Beckmann M., Draper J., Smith A.R., Taylor J., Fiehn O., Goodacre R., Bino R., Hall R., Kopka J., Lange B.M., Liu J.R., Mendes P., Nikolau B.J., Oliver S.G., Paton N.W., Roessner-Tunali U., Saito K., Smedsgaard J., Sumner L.W., Wurtele E.S., Kell D.B. (2004) A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnol. 22, 1601-1606.

Bino R.J., Hall R.D., Fiehn O., Kopka J., Saito K., Draper J., Nikolau B.J., Mendes P., Roessner-Tunali U., Beale M.H., Trethewey R.N., Lange B.M., Wurtele E.S., Sumner L.W. (2004) Potential of metabolomics as a functional genomics tool. Trends Plant Sci. 9, 418-425.

Lange B.M., Presting G.G. (2004) Genomic survey of metabolic pathways in rice, In Recent Advances in Phytochemistry , Romeo, T., ed., Elsevier Science, Amsterdam, pp. 111-137. Link

Bick J.A., Lange B.M. (2003) Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane. Arch. Biochem. Biophys. 415, 146-154.

Laule O., Führholz A., Chang H.S., Zhu T., Wang X., Heifetz P.B., Gruissem W., Lange B.M. (2003) Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 100, 6866-6871.

Lange B.M., Ghassemian M. (2003) Genome organization in Arabidopsis thaliana : a survey for genes involved in isoprenoid and chlorophyll metabolism. Plant Mol. Biol. 51, 923-946.

Koller A., Washburn M.P., Lange B.M., Andon N.L., Deciu C., Haynes P.A., Hays L., Schieltz D., Ulaszek R., Wei J., Wolters D., Yates J.R. (2002) Proteomic survey of metabolic pathways in rice. Proc. Natl. Acad. Sci. USA 99, 11969-11974 (COVER STORY).

Goff S.A., Ricke D., Lan T.H., Presting G., Wang R., Dunn M., Glazebrook J., Sessions A., Oeller P., Varma H., Hadley D., Hutchison D., Martin C., Katagiri F., Lange B.M. et al. (2002) A draft sequence of the rice genome (Oryza sativa L. ssp. japonica ). Science 296, 92-100 (COVER STORY).

Lange B.M., Ketchum R.E.B. (2002) Functional genomics approaches to unravel essential oil biosynthesis. In Phytochemistry in the Genomics and Post-Genomics Eras, Recent Advances in Phytochemistry Vol. 36, Romeo, T., Dixon , R.A., eds., Elsevier Science, Amsterdam, pp. 145-162. Link

Lange B.M., Ketchum R.E.B., Croteau R. (2001) Isoprenoid biosynthesis: metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. Plant Physiol . 127, 305-314.

Heifetz P.B., Lange B.M. (2001) Genomics: integrated approaches to understand phytochemical pathways. In Biologically-Active Phytochemicals in Foods , Pfannhauser, W., Fenwick, G.R., Khokhar, S., eds., Royal Society of Chemistry, Cambridge, UK , pp. 567-575. no link available

Sandermann H., Hertkorn N, May R.G., Lange B.M. (2001) Bound pesticidal residues in crop plants: chemistry, bioavailability, and toxicology. In Pesticide Biotransformation in Plants and Microorganisms , ACS Symposium Series 777, Hall, J.C., Hoagland R.E., Zablotowicz R.M., eds., Oxford University Press, USA, pp. 119-128. no link available

Lange, B.M., Rujan, T., Martin, W., Croteau, R. (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc. Natl. Acad. Sci. USA 97, 13172-13177.

Lange B.M., Wildung M.R., Stauber E., Sanchez C., Pouchnik D., Croteau R. (2000) Probing essential oil biosynthesis and storage by evaluation of expressed sequence tags from mint glandular trichomes. Proc. Natl. Acad. Sci. USA 97, 2934-2939.

Lange B.M., Croteau R. (1999) Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. Proc. Natl. Acad. Sci. USA 96, 13714-13719.

Lange B.M., Croteau R. (1999) Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: cloning and heterologous expression of 1-deoxyxylulose-5-phosphate reductoisomerase from peppermint. Arch. Biochem. Biophys. 365, 170-174.

Lange B.M., Croteau R. (1999) Genetic engineering of essential oil production in mint. Curr. Op. Plant Biol. 2, 139-144.

Lange B.M., Wildung M.R., McCaskill D., Croteau R. (1998) A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. Proc. Natl. Acad. Sci. USA 95, 2100-2104.

Lange B.M., Severin K., Bechthold A., Heide L. (1998) Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures. Planta 204, 234-241.

Lange B.M., Hertkorn N., Sandermann H. (1998) Chloroaniline/lignin conjugates as model system for nonextractable pesticide residues in crop plants, Eviron. Sci. Technol. 32, 2113-2118. Link

Lange B.M., Lapierre C., Monties B., Sandermann H. (1995) Elicitor-induced spruce ( Picea abies [L.] Karst) stress lignin: structural similarity to early developmental lignins, Plant Physiol. 108, 1277-1287.

Lange B.M., Trost M., Heller W., Langebartels C., Sandermann H. (1994) Elicitor-induced formation of free and cell-wall-bound stilbenes in cell-suspension cultures of Scots pine ( Pinus sylvestris L.). Planta 194, 143-14. Link

Boudet A.M., Hawkins S., Cabané M., Ernst D., Galliano H., Heller W., Lange B.M., Sandermann H., Lapierre C (1994) Developmental and Stress Lignification. In EUROSILVA Contributions to Forest Tree Physiology, INRA Editions, Paris, pp. 13-34. no link available

Lange B.M., Trost M., Heller W., Sandermann H (1994) Elicitor induction of stilbene metabolism in Scots pine cell suspension cultures. Acta Horticult. 381, 199-202. no link available

Patents and PCTs

Lange B.M., Turner G.W., Rios-Estepa R. (2010) Production of small molecules in glandular trichome-bearing plants. US2010/028789, WO/2010/111571.

Lange B.M., Ghassemian M., Briggs S.P., Cooper B., Glazebrook J., Goff, S.A., Katagiri F., Kreps J., Moughamer T., Provart N., Ricke D., Zhu T. (2004) Identification and characterization of plant genes. US 20040010815.

Croteau R., Lange B.M., Wildung M.R. (2001) Plant oil gland nucleic acid molecules and methods of use. US 0102567, WO 01/53319.

Croteau R., Lange B.M. (2001) Nucleic acid molecules encoding isopentenyl monophosphate kinase and methods of use. US 6235514, WO 01/32907.

Croteau R., Lange B.M. (2000) 1-Deoxy-D-xylulose-5-phosphate reductoisomerase and methods of use. US 6281017, WO 00/46346.

Croteau R., Lange B.M., Wildung M.R., McCaskill D. (1999) Nucleic and amino acid sequences for a novel transketolase from Mentha x piperita. US 6190895, WO 99/11757.