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Secretory Structures

Project Goals:..............Elucidating the physiology and biochemistry of anatomical structures that evolved to accumulate secretions
......................Department of Energy - Energy Biosciences Program
.............Gregg Howe - Michigan State University

Executive Summary

Secretory structures in terrestrial plants appear to have first emerged as intracellular oil bodies in liverworts. In vascular plants, internal secretory structures, such as resin ducts and laticifers, are usually found in conjunction with vascular bundles, whereas subepidermal secretory cavities and epidermal glandular trichomes generally have more complex tissue distribution patterns. The primary function of plant secretory structures is related to defense responses, both constitutive and induced, against herbivores and pathogens. The ability to sequester secondary (or specialized) metabolites and defense proteins in secretory structures was a critical adaptation that shaped plant-herbivore and plant-pathogen interactions. We are using integrative approaches - which include anatomical measurements and statistical analyses, physiological studies, transcriptomics/proteomics/metabolomics - to generate input data for mathematical models that capture flux distribution across primary and specialzied metabolism.

Online databases and toolkits

YASMEnv - A set of tools to create and analyze stoichiometric metabolic models.

Mint Genomics Resource - Database for all aspects of research on the mint family

Selected Recent Publications

Zager J.J., Lange I., Srividya N., Smith A., Lange B.M. (2019) Gene networks underlying cannabinoid and terpenoid accumulation in cannabis. Plant Physiol. 180, 1877-1897.

Lange B.M., Srividya N. (2019) Enzymology of monoterpene functionalization in glandular trichomes. J. Exp. Bot., 70, 1095-1108.

Turner G.W., Parrish A.N., Zager J.J., Fischedick J.T., Lange B.M. (2019) Assessment of flux through oleoresin biosynthesis in epithelial cells of loblolly pine resin ducts. J. Exp. Bot. 70, 217-230.

Zager J.J., Lange B.M. (2018) Assessing flux distribution associated with metabolic specialization of glandular trichomes. Trends Plant Sci. 23, 638-647.

Liu C., Srividya N., Parrish A.N., Yue W., Shan M., Wu Q., Lange B.M. (2018) Morphology of glandular trichomes of Japanese catnip (Schizonepeta tenuifolia Briquet) and developmental dynamics of their secretory activity. Phytochemistry 150, 23-30.

Johnson S.R., Lange I., Srividya N., Lange B.M. (2017) Bioenergetics of monoterpenoid essential oil biosynthesis in non-photosynthetic glandular trichomes. Plant Physiol. 175, 681-695.

Turner G.W., Lange B.M. (2015) Ultrastructure of grapefruit secretory cavities and immunocytochemical localization of (+)-limonene synthase. Int. J. Plant Sci., 176, 643-661. Link

Lange B.M. (2015) The evolution of plant secretory structures and emergence of terpenoid chemical diversity. Annu. Rev. Plant Biol. 66, 139-159.